Visfatin and 25-Hydroxyvitamin D 3 Levels Affect Coronary Collateral Circulation Development in Patients with Chronic Coronary Total Occlusion

Abstract

Background: Coronary collateral circulation (CCC) plays a vital role in the myocardial blood supply, especially for ischemic myocardium. Evidence suggests that the visfatin and 25-hydroxyvitamin D 3 [25(OH)D 3 ] levels are related to the degree and incidence of vascular stenosis associated with coronary artery disease; however, few studies have evaluated the effect of visfatin and 25(OH)D 3 on CCC development in patients with chronic total occlusion (CTO). This study aimed to evaluate the relationship between the serum visfatin and 25(OH)D 3 levels and CCC in patients with CTO. Methods: A total of 189 patients with CTO confirmed by coronary angiography were included. CCC was graded from 0 to 3 according to the Rentrop-Cohen classification. Patients with grade 0 or grade 1 collateral development were included in the poor CCC group ( n =82), whereas patients with grade 2 or grade 3 collateral development were included in the good CCC group ( n =107). The serum visfatin and 25(OH)D 3 levels were measured by ELISA. Results: The visfatin level was significantly higher in the poor CCC group than in the good CCC group, and the 25(OH)D 3 level was significantly lower in the poor CCC group than in the good CCC group (P=0.000). Correlation analysis showed that the Rentrop grade was negatively correlated with the visfatin level ( r =−0.692, P=0.000) but positively correlated with the 25(OH)D 3 level ( r =0.635, P=0.000). Logistic regression analysis showed that the visfatin and 25(OH)D 3 levels were independent risk factors for CCC (odds ratio 1.597, 95% confidence interval 1.300–1.961, P=0.000 and odds ratio 0.566, 95% confidence interval 0.444–0.722, P=0.000, respectively). The visfatin and 25(OH)D 3 levels can effectively predict the CCC status. Conclusion: Serum visfatin and 25(OH)D 3 levels are related to CCC development and are independent predictors of poor CCC.