Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Stefania Crotta; Matteo Villa; Jack Major; Katja Finsterbusch; Miriam Llorian; Peter Carmeliet; Joerg Buescher; Andreas Wack

doi:10.1038/s41467-023-36352-z

Nature Communications (Feb 2023)

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Stefania Crotta,
Matteo Villa,
Jack Major,
Katja Finsterbusch,
Miriam Llorian,
Peter Carmeliet,
Joerg Buescher,
Andreas Wack

Affiliations

Stefania Crotta: Immunoregulation Laboratory, Francis Crick Institute
Matteo Villa: Max Planck Institute of Immunobiology and Epigenetics
Jack Major: Immunoregulation Laboratory, Francis Crick Institute
Katja Finsterbusch: Immunoregulation Laboratory, Francis Crick Institute
Miriam Llorian: Bioinformatics, Francis Crick Institute
Peter Carmeliet: Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, and Department of Oncology, KU Leuven
Joerg Buescher: Max Planck Institute of Immunobiology and Epigenetics
Andreas Wack: Immunoregulation Laboratory, Francis Crick Institute

DOI: https://doi.org/10.1038/s41467-023-36352-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

Read online

Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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