PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

Abstract

A PEG-mediated green synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin- 4(3H)-ones was developed starting from 6-iodo-3-methyl-2-phenylquinazolin- 4(3H)-one by means of quinazolinone-based internal alkyne/1,2-diketone as intermediates using the Castro–Stephen coupling reaction/potassium permanganate mediated oxidation and cyclocondensation reactions.

Keywords

• kmno4
• bisazaheterocycle
• 1,2-diamine
• 1,2-diketone