SUBCLINICAL INFLAMMATION BIOMARKERS IN AN INFANT-JUVENILE PATIENTS WITH TYPE 1 DIABETES

Abstract

Type 1 diabetes (T1D) is associated with an increased risk of vascular complications. Proinflammatory cytokines IL-6, MCP-1 and TNF-α, have been implicated in the development of these complications. The aim of this study was to determine the plasma levels of IL-6, MCP-1, TNF-α, hsPCR and fibrinogen (Fg) in patients with infant-juvenile DT1 and its association with the glycemic control degree and time to progression of disease. Forty-five DT1 patients (24 m/21 w), age 11,2±1,8 years, with a time to progression of disease of 3,1±3,0 years, without vascular complications, were studied and compared with 20 healthy subjects. Plasma levels of IL-6, MCP-1 and TNF-α, Fg, hsPCR, leukocyte count, fasting blood glucose and HbA1c were determined. The presence of retinopathy and nephropathy was rule out. Data were analyzed with the Windows software SPSS 15. Diabetic children had higher levels of IL-6 (1,10±0,74 vs 0,68±0,19 pg/ml; p=0,005), MCP-1 (130±49 vs 95±18 pg/ml, p=0,02), hsPCR (1,02±1,07 vs 0,43 ±026 mg/l; p=0,007) Fg (299±59 vs 246±18 mg/dl, p=0,0001) with respect to controls. No significant difference of TNF-α between both groups were observed. When diabetic patients were grouped according to glycemic control degree (HbA1c 3 years), no significant differences were found in the molecules studied. In diabetic patients, HbA1c was correlated with IL-6, MCP-1 and hsPCR. These results reflect a proinflammatory state in the diabetic population studied.

Keywords

• diabetes
• inflamación subclínica
• citoquinas proinflamatorias
• pcrus.