Frontiers in Nutrition (May 2022)

Prognostic Roles of Glucose to Lymphocyte Ratio and Modified Glasgow Prognosis Score in Patients With Non-small Cell Lung Cancer

  • Ming Yang,
  • Ming Yang,
  • Ming Yang,
  • Qi Zhang,
  • Qi Zhang,
  • Qi Zhang,
  • Yi-Zhong Ge,
  • Yi-Zhong Ge,
  • Yi-Zhong Ge,
  • Yi-Zhong Ge,
  • Meng Tang,
  • Meng Tang,
  • Meng Tang,
  • Chun-Lei Hu,
  • Chun-Lei Hu,
  • Chun-Lei Hu,
  • Zi-Wen Wang,
  • Zi-Wen Wang,
  • Zi-Wen Wang,
  • Xi Zhang,
  • Xi Zhang,
  • Xi Zhang,
  • Meng-Meng Song,
  • Meng-Meng Song,
  • Meng-Meng Song,
  • Guo-Tian Ruan,
  • Guo-Tian Ruan,
  • Guo-Tian Ruan,
  • Xiao-Wei Zhang,
  • Xiao-Wei Zhang,
  • Xiao-Wei Zhang,
  • Tong Liu,
  • Tong Liu,
  • Tong Liu,
  • Hai-Lun Xie,
  • Hai-Lun Xie,
  • Hai-Lun Xie,
  • He-Yang Zhang,
  • He-Yang Zhang,
  • He-Yang Zhang,
  • Kang-Ping Zhang,
  • Kang-Ping Zhang,
  • Kang-Ping Zhang,
  • Qin-Qin Li,
  • Qin-Qin Li,
  • Qin-Qin Li,
  • Xiang-Rui Li,
  • Xiang-Rui Li,
  • Xiang-Rui Li,
  • Xiao-Yue Liu,
  • Xiao-Yue Liu,
  • Xiao-Yue Liu,
  • Shi-Qi Lin,
  • Shi-Qi Lin,
  • Shi-Qi Lin,
  • Shi-Qi Lin,
  • Han-Ping Shi,
  • Han-Ping Shi,
  • Han-Ping Shi

DOI
https://doi.org/10.3389/fnut.2022.871301
Journal volume & issue
Vol. 9

Abstract

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BackgroundNon-small cell lung cancer (NSCLC) is among the most prevalent malignancies worldwide. Previous studies have shown that the status of inflammation, nutrition and immune are closely related to overall survival (OS) of patients with NSCLC, but little is known about their interactive and combined roles. Hence, we chose glucose to lymphocyte ratio (GLR) and modified Glasgow Prognosis Score (mGPS) as prognostic factors and assessed the prognostic values of them for patients with NSCLC.MethodsBaseline clinicopathologic and laboratory characteristics of 862 patients with NSCLC were obtained from a multicenter prospective cohort. The Cox proportional hazard regression models were used to determine prognostic values of the clinical factors. A nomogram was also constructed integrating the clinical factors with clinical significance or independent prognostic values. Concordance index (C-index) was utilized to evaluate the prediction accuracy of the TNM stage and the nomogram.ResultsMultivariate analyses demonstrated that GLR [Hazard ratio (HR) = 1.029, 95% confidence interval (CI) = 1.004–1.056, P = 0.023] and mGPS (score of 1: HR = 1.404, 95% CI = 1.143–1.726, P = 0.001; score of 2: HR = 1.515, 95% CI = 1.159–1.980, P = 0.002) were independent prognostic factors for patients with NSCLC. The C-indexes of the TNM stage and the nomogram were 0.642 (95% CI = 0.620–0.663) and 0.694 (95% CI = 0.671–0.717), respectively.ConclusionGLR and mGPS were independent prognostic factors for patients with NSCLC. Moreover, our constructed nomogram might be superior in predicting prognosis of patients with NSCLC compared with the TNM stage.

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