Nature Communications (Mar 2023)
Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
- Eduardo Gomez-Bañuelos,
- Yikai Yu,
- Jessica Li,
- Kevin S. Cashman,
- Merlin Paz,
- Maria Isabel Trejo-Zambrano,
- Regina Bugrovsky,
- Youliang Wang,
- Asiya Seema Chida,
- Cheryl A. Sherman-Baust,
- Dylan P. Ferris,
- Daniel W. Goldman,
- Erika Darrah,
- Michelle Petri,
- Iñaki Sanz,
- Felipe Andrade
Affiliations
- Eduardo Gomez-Bañuelos
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Yikai Yu
- Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Jessica Li
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Kevin S. Cashman
- Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University
- Merlin Paz
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Maria Isabel Trejo-Zambrano
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Regina Bugrovsky
- Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University
- Youliang Wang
- Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University
- Asiya Seema Chida
- Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University
- Cheryl A. Sherman-Baust
- Gene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging
- Dylan P. Ferris
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Daniel W. Goldman
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Erika Darrah
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Michelle Petri
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- Iñaki Sanz
- Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University
- Felipe Andrade
- Division of Rheumatology, The Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-37083-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.
