The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

Nicholas Jochumsen; Rasmus L. Marvig; Søren Damkiær; Rune Lyngklip Jensen; Wilhelm Paulander; Søren Molin; Lars Jelsbak; Anders Folkesson

doi:10.1038/ncomms13002

Nature Communications (Oct 2016)

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

Nicholas Jochumsen,
Rasmus L. Marvig,
Søren Damkiær,
Rune Lyngklip Jensen,
Wilhelm Paulander,
Søren Molin,
Lars Jelsbak,
Anders Folkesson

Affiliations

Nicholas Jochumsen: Department of Systems Biology, Technical University of Denmark
Rasmus L. Marvig: Department of Systems Biology, Technical University of Denmark
Søren Damkiær: Department of Systems Biology, Technical University of Denmark
Rune Lyngklip Jensen: Department of Systems Biology, Technical University of Denmark
Wilhelm Paulander: Department of Veterinary Disease Biology, University of Copenhagen
Søren Molin: Department of Systems Biology, Technical University of Denmark
Lars Jelsbak: Department of Systems Biology, Technical University of Denmark
Anders Folkesson: National Veterinary Institute, Technical University of Denmark

DOI: https://doi.org/10.1038/ncomms13002
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Colistin is an antibiotic used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Here, Jochumsen et al. reconstruct the pathways for the molecular evolution of colistin resistance in P. aeruginosaand show that the number of pathways is highly constrained by interactions among genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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