Synthesis of Novel Sulfonamide Derivatives Featuring 1-(Methylsulfonyl)-4-(2,3,4-Trimethoxybenzyl)Piperazine Core Structures

Iliyan Ivanov; Stanimir Manolov; Dimitar Bojilov; Diyana Dimitrova; Paraskev Nedialkov

doi:10.3390/M1879

Molbank (Sep 2024)

Synthesis of Novel Sulfonamide Derivatives Featuring 1-(Methylsulfonyl)-4-(2,3,4-Trimethoxybenzyl)Piperazine Core Structures

Iliyan Ivanov,
Stanimir Manolov,
Dimitar Bojilov,
Diyana Dimitrova,
Paraskev Nedialkov

Affiliations

Iliyan Ivanov: Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria
Stanimir Manolov: Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria
Dimitar Bojilov: Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria
Diyana Dimitrova: Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria
Paraskev Nedialkov: Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria

DOI: https://doi.org/10.3390/M1879
Journal volume & issue: Vol. 2024, no. 3
p. M1879

Abstract

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Herein we report the synthesis of three novel sulfonamide derivatives of trimetazidine—medication primarily used to treat angina pectoris. The new compounds have been fully characterized with their melting point, 1H- and 13C-NMR, UV, and mass spectrometry. The collected data confirm the successful synthesis and structural integrity of the new molecules.

Published in Molbank

ISSN: 1422-8599 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Inorganic chemistry
Website: https://www.mdpi.com/journal/molbank

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