Nature Communications (Oct 2019)
IRF2 is a master regulator of human keratinocyte stem cell fate
- Nicolas Mercado,
- Gabi Schutzius,
- Christian Kolter,
- David Estoppey,
- Sebastian Bergling,
- Guglielmo Roma,
- Caroline Gubser Keller,
- Florian Nigsch,
- Adrian Salathe,
- Remi Terranova,
- John Reece-Hoyes,
- John Alford,
- Carsten Russ,
- Judith Knehr,
- Dominic Hoepfner,
- Alexandra Aebi,
- Heinz Ruffner,
- Tanner C. Beck,
- Sajjeev Jagannathan,
- Calla M. Olson,
- Hadley E. Sheppard,
- Selma Z. Elsarrag,
- Tewis Bouwmeester,
- Mathias Frederiksen,
- Felix Lohmann,
- Charles Y. Lin,
- Susan Kirkland
Affiliations
- Nicolas Mercado
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Gabi Schutzius
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Christian Kolter
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- David Estoppey
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Sebastian Bergling
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Guglielmo Roma
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Caroline Gubser Keller
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Florian Nigsch
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Adrian Salathe
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Remi Terranova
- Preclinical Safety, Translational Medicine, NIBR
- John Reece-Hoyes
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- John Alford
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Carsten Russ
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research
- Judith Knehr
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Dominic Hoepfner
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Alexandra Aebi
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Heinz Ruffner
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Tanner C. Beck
- Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Sajjeev Jagannathan
- Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Calla M. Olson
- Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Hadley E. Sheppard
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Selma Z. Elsarrag
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Tewis Bouwmeester
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Mathias Frederiksen
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- Felix Lohmann
- Autoimmunity, Transplantation and Inflammation, NIBR
- Charles Y. Lin
- Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Susan Kirkland
- Chemical Biology & Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus
- DOI
- https://doi.org/10.1038/s41467-019-12559-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.
