EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE

Abstract

Aim. To study the effect of simvastatin added to standard therapy on the left ventricular structure functional status in patients with diastolic chronic heart failure (CHF).Material and methods. Patients (n=125) with diastolic CHF (relaxation disturbances and pseudonormalization) were included into the open nonrandomized study. Patients of the main group (n=66) received simvastatin additionally to standard therapy of CHF. Patients of control group (n=59) received standard therapy only. Initially and after 6 months of treatment Doppler echocardiography (EchoCG) was performed with assessment of transmitral blood flow indices. On the basis of EchoCG data diastolic dysfunction types were determined in patients of the main group. Dynamics of EchoCG indices were evaluated in accordance with these types.Results. Significant increase in E (peak early diastolic left ventricular filling velocity) value by 14.1% (p<0.001) and E/A (where A - peak left ventricular filling velocity at atrial contraction) ratio by 18.7% (p<0.001) was found in the main group in estimating of transmitral flow indicators. Deceleration time of early diastolic filling significantly decreased by 7.8% (p<0.01). Other parameters did not change significantly both in the main and control groups. Intra-group comparison in the main group demonstrated that transmitral blood flow indices changed significantly only in patients with delayed relaxation (type I of diastolic dysfunction).Conclusion. Simvаstatin added to standard therapy of CHF resulted in significant improvement in the left ventricle diastolic function.

Keywords

• диастолическая дисфункция левого желудочка
• симвастатин
• хроническая сердечная недостаточность