Nature Communications (Mar 2019)
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
- Cristina López,
- Kortine Kleinheinz,
- Sietse M. Aukema,
- Marius Rohde,
- Stephan H. Bernhart,
- Daniel Hübschmann,
- Rabea Wagener,
- Umut H. Toprak,
- Francesco Raimondi,
- Markus Kreuz,
- Sebastian M. Waszak,
- Zhiqin Huang,
- Lina Sieverling,
- Nagarajan Paramasivam,
- Julian Seufert,
- Stephanie Sungalee,
- Robert B. Russell,
- Julia Bausinger,
- Helene Kretzmer,
- Ole Ammerpohl,
- Anke K. Bergmann,
- Hans Binder,
- Arndt Borkhardt,
- Benedikt Brors,
- Alexander Claviez,
- Gero Doose,
- Lars Feuerbach,
- Andrea Haake,
- Martin-Leo Hansmann,
- Jessica Hoell,
- Michael Hummel,
- Jan O. Korbel,
- Chris Lawerenz,
- Dido Lenze,
- Bernhard Radlwimmer,
- Julia Richter,
- Philip Rosenstiel,
- Andreas Rosenwald,
- Markus B. Schilhabel,
- Harald Stein,
- Stephan Stilgenbauer,
- Peter F. Stadler,
- Monika Szczepanowski,
- Marc A. Weniger,
- Marc Zapatka,
- Roland Eils,
- Peter Lichter,
- Markus Loeffler,
- Peter Möller,
- Lorenz Trümper,
- Wolfram Klapper,
- ICGC MMML-Seq Consortium,
- Steve Hoffmann,
- Ralf Küppers,
- Birgit Burkhardt,
- Matthias Schlesner,
- Reiner Siebert
Affiliations
- Cristina López
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Kortine Kleinheinz
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Sietse M. Aukema
- Institute of Human Genetics, Christian-Albrechts-University
- Marius Rohde
- Pediatric Hematology and Oncology, University Hospital Giessen
- Stephan H. Bernhart
- Interdisciplinary Center for Bioinformatics, University of Leipzig
- Daniel Hübschmann
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Rabea Wagener
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Umut H. Toprak
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Francesco Raimondi
- Cell Networks, Bioquant and Biochemistry CenterBiochemie Zentrum Heidelberg (BZH), University of Heidelberg
- Markus Kreuz
- Institute for Medical Informatics Statistics and Epidemiology
- Sebastian M. Waszak
- Genome Biology Unit, EMBL Heidelberg
- Zhiqin Huang
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Lina Sieverling
- Faculty of Biosciences, Heidelberg University
- Nagarajan Paramasivam
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Julian Seufert
- Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ)
- Stephanie Sungalee
- Genome Biology Unit, EMBL Heidelberg
- Robert B. Russell
- Cell Networks, Bioquant and Biochemistry CenterBiochemie Zentrum Heidelberg (BZH), University of Heidelberg
- Julia Bausinger
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Helene Kretzmer
- Interdisciplinary Center for Bioinformatics, University of Leipzig
- Ole Ammerpohl
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Anke K. Bergmann
- Institute of Human Genetics, Christian-Albrechts-University
- Hans Binder
- Interdisciplinary Center for Bioinformatics, University of Leipzig
- Arndt Borkhardt
- Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University
- Benedikt Brors
- Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ)
- Alexander Claviez
- Department of Pediatrics, University Hospital Schleswig-Holstein
- Gero Doose
- Interdisciplinary Center for Bioinformatics, University of Leipzig
- Lars Feuerbach
- Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ)
- Andrea Haake
- Institute of Human Genetics, Christian-Albrechts-University
- Martin-Leo Hansmann
- Senckenberg Institute of Pathology, University of Frankfurt Medical School
- Jessica Hoell
- Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University
- Michael Hummel
- Institute of Pathology, Charité – University Medicine Berlin
- Jan O. Korbel
- Genome Biology Unit, EMBL Heidelberg
- Chris Lawerenz
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Dido Lenze
- Institute of Pathology, Charité – University Medicine Berlin
- Bernhard Radlwimmer
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Julia Richter
- Institute of Human Genetics, Christian-Albrechts-University
- Philip Rosenstiel
- Institute of Clinical Molecular Biology, Christian-Albrechts-University
- Andreas Rosenwald
- Institute of Pathology, Comprehensive Cancer Center Mainfranken, University of Würzburg
- Markus B. Schilhabel
- Institute of Clinical Molecular Biology, Christian-Albrechts-University
- Harald Stein
- Pathodiagnostik Berlin
- Stephan Stilgenbauer
- Department for Internal Medicine III, Ulm University
- Peter F. Stadler
- Bioinformatics Group, Department of Computer, University of Leipzig
- Monika Szczepanowski
- Hematopathology Section, Christian-Albrechts-University
- Marc A. Weniger
- Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen
- Marc Zapatka
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Roland Eils
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Peter Lichter
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Markus Loeffler
- Institute for Medical Informatics Statistics and Epidemiology
- Peter Möller
- Institute of Pathology, University of Ulm and University Hospital of Ulm
- Lorenz Trümper
- Department of Hematology and Oncology, Georg-August-University of Göttingen
- Wolfram Klapper
- Hematopathology Section, Christian-Albrechts-University
- ICGC MMML-Seq Consortium
- Steve Hoffmann
- Interdisciplinary Center for Bioinformatics, University of Leipzig
- Ralf Küppers
- Institute of Cell Biology (Cancer Research), Medical School, University of Duisburg-Essen
- Birgit Burkhardt
- University Hospital Münster - Pediatric Hematology and Oncology
- Matthias Schlesner
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Reiner Siebert
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-08578-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.
