Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water

Julia Y. Rho; Henry Cox; Edward D. H. Mansfield; Sean H. Ellacott; Raoul Peltier; Johannes C. Brendel; Matthias Hartlieb; Thomas A. Waigh; Sébastien Perrier

doi:10.1038/s41467-019-12586-8

Nature Communications (Oct 2019)

Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water

Julia Y. Rho,
Henry Cox,
Edward D. H. Mansfield,
Sean H. Ellacott,
Raoul Peltier,
Johannes C. Brendel,
Matthias Hartlieb,
Thomas A. Waigh,
Sébastien Perrier

Affiliations

Julia Y. Rho: Department of Chemistry, University of Warwick
Henry Cox: Biological Physics, School of Physics and Astronomy, University of Manchester
Edward D. H. Mansfield: Department of Chemistry, University of Warwick
Sean H. Ellacott: Department of Chemistry, University of Warwick
Raoul Peltier: Department of Chemistry, University of Warwick
Johannes C. Brendel: Department of Chemistry, University of Warwick
Matthias Hartlieb: Department of Chemistry, University of Warwick
Thomas A. Waigh: Biological Physics, School of Physics and Astronomy, University of Manchester
Sébastien Perrier: Department of Chemistry, University of Warwick

DOI: https://doi.org/10.1038/s41467-019-12586-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Reversibility of peptide hydrogen bonded supramolecular assemblies makes them tunable but highly dynamic and prone to disassembly at the low concentration. Here the authors show a secondary hydrophobic interaction, near the peptide core that stabilises the peptide bonds, without losing the solubility of the systems in aqueous conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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