Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H) Under Solvent-Free Conditions

Abstract

In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one-pot Biginelli condensation in the presence of gypsum as an environmental friendly and recycled catalyst.