Nature Communications (May 2018)
Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
- Carolin Seuring,
- Kartik Ayyer,
- Eleftheria Filippaki,
- Miriam Barthelmess,
- Jean-Nicolas Longchamp,
- Philippe Ringler,
- Tommaso Pardini,
- David H. Wojtas,
- Matthew A. Coleman,
- Katerina Dörner,
- Silje Fuglerud,
- Greger Hammarin,
- Birgit Habenstein,
- Annette E. Langkilde,
- Antoine Loquet,
- Alke Meents,
- Roland Riek,
- Henning Stahlberg,
- Sébastien Boutet,
- Mark S. Hunter,
- Jason Koglin,
- Mengning Liang,
- Helen M. Ginn,
- Rick P. Millane,
- Matthias Frank,
- Anton Barty,
- Henry N. Chapman
Affiliations
- Carolin Seuring
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Kartik Ayyer
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Eleftheria Filippaki
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Miriam Barthelmess
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Jean-Nicolas Longchamp
- Physics Department of the University of Zurich
- Philippe Ringler
- Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel
- Tommaso Pardini
- Lawrence Livermore National Laboratory
- David H. Wojtas
- Department of Electrical and Computer Engineering, University of Canterbury
- Matthew A. Coleman
- Lawrence Livermore National Laboratory
- Katerina Dörner
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Silje Fuglerud
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Greger Hammarin
- Department of Chemistry and Molecular Biology
- Birgit Habenstein
- CNRS, CBMN UMR5248, IECB, Université de Bordeaux
- Annette E. Langkilde
- Department of Drug Design and Pharmacology, University of Copenhagen
- Antoine Loquet
- CNRS, CBMN UMR5248, IECB, Université de Bordeaux
- Alke Meents
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Roland Riek
- Laboratory of Physical Chemistry, ETH Zürich
- Henning Stahlberg
- Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel
- Sébastien Boutet
- Linac Coherent Light Source, SLAC National Accelerator Laboratory
- Mark S. Hunter
- Linac Coherent Light Source, SLAC National Accelerator Laboratory
- Jason Koglin
- Linac Coherent Light Source, SLAC National Accelerator Laboratory
- Mengning Liang
- Linac Coherent Light Source, SLAC National Accelerator Laboratory
- Helen M. Ginn
- Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford
- Rick P. Millane
- Department of Electrical and Computer Engineering, University of Canterbury
- Matthias Frank
- Lawrence Livermore National Laboratory
- Anton Barty
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- Henry N. Chapman
- Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron
- DOI
- https://doi.org/10.1038/s41467-018-04116-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.
