PLoS ONE (Jan 2020)

Efficacy of surgical management for recurrent intrahepatic cholangiocarcinoma: A multi-institutional study by the Okayama Study Group of HBP surgery.

  • Toru Kojima,
  • Yuzo Umeda,
  • Tomokazu Fuji,
  • Takefumi Niguma,
  • Daisuke Sato,
  • Yoshikatsu Endo,
  • Kenta Sui,
  • Masaru Inagaki,
  • Masahiro Oishi,
  • Tetsuya Ota,
  • Katsuyoshi Hioki,
  • Tadakazu Matsuda,
  • Hideki Aoki,
  • Ryuji Hirai,
  • Masashi Kimura,
  • Takahito Yagi,
  • Toshiyoshi Fujiwara

DOI
https://doi.org/10.1371/journal.pone.0238392
Journal volume & issue
Vol. 15, no. 9
p. e0238392

Abstract

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BackgroundThe prognosis of intrahepatic cholangiocarcinoma (ICC) has been poor, because of the high recurrence rate even after curative surgery. This study aimed to evaluate the prognostic impact of surgical resection of recurrent ICC.Patients and methodsA total of 345 cases of ICC who underwent hepatectomy with curative intent in 17 institutions were retrospectively analyzed, focusing on recurrence patterns and treatment modalities for recurrent ICC.ResultsMedian survival time and overall 5-year recurrence-free survival rate were 17.8 months and 28.5%, respectively. Recurrences (n = 223) were classified as early (recurrence at ≤1 year, n = 131) or late (recurrence at >1 year, n = 92). Median survival time was poorer for early recurrence (16.3 months) than for late recurrence (47.7 months, pConclusionSurgical resection of recurrent ICC could improve survival after recurrence, especially for patients with intra- or extrahepatic recurrence as resectable oligo-metastases.