Neuropsychiatric Disease and Treatment (Dec 2024)
Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study
Abstract
Zhijun Cui,1 Aimin Liang,1 Hongmei Huang,1 Xin Ni2 1Children’s Health Care Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of China; 2Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, People’s Republic of ChinaCorrespondence: Hongmei Huang; Xin Ni, Email [email protected]; [email protected]: This study investigated whether abnormal cerebral activity observed in adolescents and adults with ADHD also occurs in children during the early developmental stages of executive function.Methods: The study included 52 children with ADHD aged 4.0– 9.0 years and 34 healthy control children. Changes in oxygenated hemoglobin (HbO) levels were measured while participants completed GO/NOGO tasks to assess brain activation and connectivity.Results: Children with ADHD demonstrated a stable prefrontal activation deficit during the GO/NOGO tasks (pFDR < 0.05). Additionally, hyperconnectivity was observed between the motor area and the prefrontal lobe in these children (uncorrected p < 0.01). The logistic regression model incorporating brain activation and connectivity features achieved an area under the ROC curve of 0.86 (95% CI, [0.78, 0.95]), with a sensitivity of 0.79 and specificity of 0.85.Conclusion: The findings suggest that prefrontal region abnormalities are present in children with ADHD at early developmental stages. This underscores the importance of targeting the prefrontal cortex in interventions and highlights the role of multi-network coordination in ADHD-related brain abnormalities. Limitations include the cross-sectional design and relatively small sample size, which should be addressed in future longitudinal studies.Keywords: attention deficit hyperactivity disorder, fNIRS, execution function, brain network
