Nature Communications (Sep 2018)

Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells

  • Xufeng Chen,
  • Jingyao Zhao,
  • Chan Gu,
  • Yu Cui,
  • Yuling Dai,
  • Guangrong Song,
  • Haifeng Liu,
  • Hao Shen,
  • Yuanhua Liu,
  • Yuya Wang,
  • Huayue Xing,
  • Xiaoyan Zhu,
  • Pei Hao,
  • Fan Guo,
  • Xiaolong Liu

DOI
https://doi.org/10.1038/s41467-018-06282-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Hematopoietic stem cells (HSCs) in the bone marrow are quiescent, but are activated in response to stress. Here, the authors show that loss of Med23 leads to greater activation and enhanced myeloid potential of HSCs in response to stress, also Med23 maintains stemness gene expression and suppresses myeloid genes.