Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: report of two cases

Abstract

We present two cases of very uncommon, undifferentiated pancreatic carcinoma (UPC) with osteoclastic cells. First case is a 52-year-old female with no previous health issues presented with unintentional, significant weight loss, not specified epigastric pain and microcytic anemia. After clinical examination the pancreatic neoplasm was found. Histopathological analysis suggested UPC. Four years later, MSCT scan discovered solid mass in lung and after histopathological analysis metastasis of UPC. Second case is a 72-year-old male with past medical history of diabetes type 2 and hypothyreosis who presented with an epigastric pain. Clinical diagnosis was pancreatic neoplasm. After histopathological examination undifferentiated pancreatic carcinoma with osteoclastic giant cells was diagnosed.

Keywords

• pancreatic neoplasms
• adenocarcinoma
• osteoclasts
• giant cells