Frontiers in Endocrinology (Feb 2021)

The Association Between Leucine and Diabetic Nephropathy in Different Gender: A Cross-Sectional Study in Chinese Patients With Type 2 Diabetes

  • Xiaoqian Gao,
  • Ruiqin Hou,
  • Xin Li,
  • Xing-Hua Qiu,
  • Hui-Huan Luo,
  • Sheng-Lin Liu,
  • Zhong-Ze Fang,
  • Zhong-Ze Fang

DOI
https://doi.org/10.3389/fendo.2020.619422
Journal volume & issue
Vol. 11

Abstract

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ObjectiveThis study aimed to evaluate how leucine are associated with diabetic nephropathy (DN) in type 2 diabetes (T2D) patients and the gender difference of this association.MethodsWe retrieved 1,031 consecutive patients with T2D who meet the inclusion and exclusion criteria from the same tertiary care center and extracted clinical information from electronic medical record. Plasma leucine was measured by liquid chromatography-mass spectrometer. Restricted cubic spline (RCS) was conducted to examine potential non-linear relationship between leucine and the risk of DN. Logistic regression was used to obtain odds ratio (OR) and confidence interval (CI). Additive interaction was used to estimate the interaction effect between leucine and gender for DN.ResultsWe found there was a negative correlation between leucine and the risk of DN. After stratifying all patients by gender, this relationship only remained significant in women (OR:0.57, CI:0.41–0.79).ConclusionsIn conclusion, T2D patients with high levels of leucine have a lower risk of developing DN in female.

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