A Systematic Review on Recent Advancements in Deep and Machine Learning Based Detection and Classification of Acute Lymphoblastic Leukemia

Abstract

Automatic Leukemia or blood cancer detection is a challenging job and is very much required in healthcare centers. It has a significant role in early diagnosis and treatment planning. Leukemia is a hematological disorder that starts from the bone marrow and affects white blood cells (WBCs). Microscopic analysis of WBCs is a preferred approach for an early detection of Leukemia since it is cost-effective and less painful. Very few literature reviews have been done to demonstrate a comprehensive analysis of deep and machine learning-based Acute Lymphoblastic Leukemia (ALL) detection. This article presents a systematic review of the recent advancements in this knowledge domain. Here, various artificial intelligence-based ALL detection approaches are analyzed in a systematic manner with merits and demits. The review of these schemes is conducted in a structured manner. For this purpose, segmentation schemes are broadly categorized into signal and image processing-based techniques, conventional machine learning-based techniques, and deep learning-based techniques. Conventional machine learning-based ALL classification approaches are categorized into supervised and unsupervised machine learning is presented. In addition, deep learning-based classification methods are categorized into Convolutional Neural Network (CNN), Recurrent Neural Network (RNN), and the Autoencoder. Then, CNN-based classification schemes are further categorized into conventional CNN, transfer learning, and other advancements in CNN. A brief discussion of these schemes and their importance in ALL classification are also presented. Moreover, a critical analysis is performed to present a clear idea about the recent research in this field. Finally, various challenging issues and future scopes are discussed that may assist readers in formulating new research problems in this domain.

Keywords

• Acute Lymphoblastic Leukemia
• blood cancer
• classification
• deep learning
• machine learning
• segmentation