Nature Communications (Oct 2018)
Microglia innately develop within cerebral organoids
- Paul R. Ormel,
- Renata Vieira de Sá,
- Emma J. van Bodegraven,
- Henk Karst,
- Oliver Harschnitz,
- Marjolein A. M. Sneeboer,
- Lill Eva Johansen,
- Roland E. van Dijk,
- Nicky Scheefhals,
- Amber Berdenis van Berlekom,
- Eduardo Ribes Martínez,
- Sandra Kling,
- Harold D. MacGillavry,
- Leonard H. van den Berg,
- René S. Kahn,
- Elly M. Hol,
- Lot D. de Witte,
- R. Jeroen Pasterkamp
Affiliations
- Paul R. Ormel
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Renata Vieira de Sá
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Emma J. van Bodegraven
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Henk Karst
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Oliver Harschnitz
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Marjolein A. M. Sneeboer
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Lill Eva Johansen
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Roland E. van Dijk
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Nicky Scheefhals
- Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8
- Amber Berdenis van Berlekom
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Eduardo Ribes Martínez
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Sandra Kling
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Harold D. MacGillavry
- Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8
- Leonard H. van den Berg
- Department of Neurology, BCRM-UMCU, Utrecht University
- René S. Kahn
- Department of Psychiatry, BCRM-UMCU, Utrecht University
- Elly M. Hol
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- Lot D. de Witte
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- R. Jeroen Pasterkamp
- Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (BCRM-UMCU), Utrecht University
- DOI
- https://doi.org/10.1038/s41467-018-06684-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.
