Ultrasound-Responsive Materials for Drug/Gene Delivery

Xiaowen Cai; Yuan Jiang; Mei Lin; Jiyong Zhang; Huanhuan Guo; Fanwen Yang; Wingnang Leung; Chuanshan Xu

doi:10.3389/fphar.2019.01650

Frontiers in Pharmacology (Jan 2020)

Ultrasound-Responsive Materials for Drug/Gene Delivery

Xiaowen Cai,
Yuan Jiang,
Mei Lin,
Jiyong Zhang,
Huanhuan Guo,
Fanwen Yang,
Wingnang Leung,
Chuanshan Xu

Affiliations

Xiaowen Cai: Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Yuan Jiang: Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Mei Lin: Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Jiyong Zhang: Department of Pediatrics, Shenzhen Maternity and Child Health Care Hospital, Shenzhen, China
Huanhuan Guo: Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Fanwen Yang: Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China
Wingnang Leung: Asia-Pacific Institute of Aging Studies, Lingnan University, Tuen Mun, Hong Kong, Hong Kong
Chuanshan Xu: Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fphar.2019.01650
Journal volume & issue: Vol. 10

Abstract

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Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

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