The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

Yana van der Weegen; Hadar Golan-Berman; Tycho E. T. Mevissen; Katja Apelt; Román González-Prieto; Joachim Goedhart; Elisheva E. Heilbrun; Alfred C. O. Vertegaal; Diana van den Heuvel; Johannes C. Walter; Sheera Adar; Martijn S. Luijsterburg

doi:10.1038/s41467-020-15903-8

Nature Communications (Apr 2020)

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

Yana van der Weegen,
Hadar Golan-Berman,
Tycho E. T. Mevissen,
Katja Apelt,
Román González-Prieto,
Joachim Goedhart,
Elisheva E. Heilbrun,
Alfred C. O. Vertegaal,
Diana van den Heuvel,
Johannes C. Walter,
Sheera Adar,
Martijn S. Luijsterburg

Affiliations

Yana van der Weegen: Department of Human Genetics, Leiden University Medical Center
Hadar Golan-Berman: Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel–Canada, The Faculty of Medicine, The Hebrew University of Jerusalem
Tycho E. T. Mevissen: Howard Hughes Medical Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Katja Apelt: Department of Human Genetics, Leiden University Medical Center
Román González-Prieto: Department of Cell and Chemical Biology, Leiden University Medical Center
Joachim Goedhart: Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam
Elisheva E. Heilbrun: Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel–Canada, The Faculty of Medicine, The Hebrew University of Jerusalem
Alfred C. O. Vertegaal: Department of Cell and Chemical Biology, Leiden University Medical Center
Diana van den Heuvel: Department of Human Genetics, Leiden University Medical Center
Johannes C. Walter: Howard Hughes Medical Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Sheera Adar: Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel–Canada, The Faculty of Medicine, The Hebrew University of Jerusalem
Martijn S. Luijsterburg: Department of Human Genetics, Leiden University Medical Center

DOI: https://doi.org/10.1038/s41467-020-15903-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

Read online

The response to DNA damage-stalled RNA polymerase II leads to the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. Here, the authors reveal the complex assembly mechanism of the TCR complex in human cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal