Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants

Felix Wojcik; Geoffrey P. Dann; Leslie Y. Beh; Galia T. Debelouchina; Raphael Hofmann; Tom W. Muir

doi:10.1038/s41467-018-03895-5

Nature Communications (Apr 2018)

Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants

Felix Wojcik,
Geoffrey P. Dann,
Leslie Y. Beh,
Galia T. Debelouchina,
Raphael Hofmann,
Tom W. Muir

Affiliations

Felix Wojcik: Department of Chemistry, Princeton University
Geoffrey P. Dann: Department of Chemistry, Princeton University
Leslie Y. Beh: Department of Chemistry, Princeton University
Galia T. Debelouchina: Department of Chemistry, Princeton University
Raphael Hofmann: Department of Chemistry, Princeton University
Tom W. Muir: Department of Chemistry, Princeton University

DOI: https://doi.org/10.1038/s41467-018-03895-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Ubiquitylation of H2B is associated with transcription and regulation of chromatin structure. Here, the authors perform an unbiased screen to identify the role of chromatin modifications on ubiquitylation of H2BK120 and characterize the crosstalk between H2BK120ub and H2A modifications and variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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