Nature Communications (Nov 2019)
Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
- Liping Dou,
- Fei Yan,
- Jiuxia Pang,
- Dehua Zheng,
- Dandan Li,
- Li Gao,
- Lijun Wang,
- Yihan Xu,
- Jinlong Shi,
- Qian Wang,
- Lei Zhou,
- Na Shen,
- Puja Singh,
- Lili Wang,
- Yonghui Li,
- Yvchi Gao,
- Tao Liu,
- Chongjian Chen,
- Aref Al-Kali,
- Mark R. Litzow,
- Young-In Chi,
- Ann M. Bode,
- Chunhui Liu,
- Haojie Huang,
- Daihong Liu,
- Guido Marcucci,
- Shujun Liu,
- Li Yu
Affiliations
- Liping Dou
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Fei Yan
- The Hormel Institute, University of Minnesota
- Jiuxia Pang
- The Hormel Institute, University of Minnesota
- Dehua Zheng
- Department of Hepatology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Dandan Li
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Li Gao
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Lijun Wang
- The Hormel Institute, University of Minnesota
- Yihan Xu
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Jinlong Shi
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Qian Wang
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Lei Zhou
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Na Shen
- The Hormel Institute, University of Minnesota
- Puja Singh
- The Hormel Institute, University of Minnesota
- Lili Wang
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Yonghui Li
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Yvchi Gao
- Annoroad Gene Technical Laboratory
- Tao Liu
- Annoroad Gene Technical Laboratory
- Chongjian Chen
- Annoroad Gene Technical Laboratory
- Aref Al-Kali
- Division of Hematology, Mayo Clinic
- Mark R. Litzow
- Division of Hematology, Mayo Clinic
- Young-In Chi
- The Hormel Institute, University of Minnesota
- Ann M. Bode
- The Hormel Institute, University of Minnesota
- Chunhui Liu
- Haoshi Biotechnical Laboratory
- Haojie Huang
- Department of Biochemistry and Molecular Biology, Mayo Clinic
- Daihong Liu
- Department of Hematology, Chinese PLA General Hospital, Medical School of Chinese PLA
- Guido Marcucci
- Department of Hematologic Malignancies Translational Science, City of Hope
- Shujun Liu
- The Hormel Institute, University of Minnesota
- Li Yu
- Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center
- DOI
- https://doi.org/10.1038/s41467-019-12960-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The oncogenic fusion protein AML1-ETO has the ability of AML1 to interact with DNA but blocks AML1-dependent transcription. Here the authors report that histone lysine methyltransferase EZH1 interacts with AML1-ETO and methylates AML1-ETO at lysine 43, promoting AML1-ETO transcriptional repression in leukemia.
