Research progress on the regulation of malignant biological behavior of glioma by miRNA-145

Abstract

Glioma is the most malignant brain tumor with high mortality. Due to its complex biological characteristics such as malignant proliferation, invasion, drug resistance, and immunosuppression, the clinical treatment faces great difficulties. Although the survival rate has improved under surgery combined with radiotherapy and chemotherapy, the overall curative effect is still not obvious. As a kind of non coding RNA (ncRNA), microRNA (miRNA) which has been extensively studied in recent years is involved in the regulation of biological processes of normal tissues and various tumors (including glioma) in human. As a cancer suppressor gene, miRNA - 145 plays a regulatory role in the progression of glioma through a variety of pathways, especially as a targeted drug transported to the tumor area through nanocarriers to treat tumors, becoming a current research hotspot. This article summarizes the role of miRNA - 145 in pathological grading, tumor microenvironment, the regulation of glioma stem cells, drug resistance, and the prognosis of glioma, aiming to provide the reference for the diagnosis and treatment of glioma.

Keywords

• glioma
• micrornas
• biomarkers
• review