Diagnosis of medullary thyroid cancer and prognostic factors of disease aggressiveness

Abstract

In the study were enrolled 137 patients with medullary thyroid cancer (MTC). Low 35%-sensitivity of FNAC and high accuracy of basal calcitonin in MTC diagnostics were found. Mutation analysis of the RET pro- tooncogene in familial and sporadic MTC, RAS -gene in sporadic MTC were done. The correlation between type of the mutation and disease aggressiveness was found.

Keywords

• medullary thyroid cancer
• multiple endocrine neoplasia syndrome type 2
• calcitonin
• cea
• ret-protooncogene
• fine-needle aspiration citology