TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

Ankur Chakravarthy; Lubaba Khan; Nathan Peter Bensler; Pinaki Bose; Daniel D. De Carvalho

doi:10.1038/s41467-018-06654-8

Nature Communications (Nov 2018)

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

Ankur Chakravarthy,
Lubaba Khan,
Nathan Peter Bensler,
Pinaki Bose,
Daniel D. De Carvalho

Affiliations

Ankur Chakravarthy: Princess Margaret Cancer Centre, University Health Network
Lubaba Khan: Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
Nathan Peter Bensler: Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
Pinaki Bose: Ohlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary
Daniel D. De Carvalho: Princess Margaret Cancer Centre, University Health Network

DOI: https://doi.org/10.1038/s41467-018-06654-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Changes in ECM are of predictive value in pancreatic and colorectal cancer prognosis. Here, the authors perform a pan-cancer analysis and find a subset of ECM genes that is linked to TGF-β signalling signature and is correlated with immunotherapy failure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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