HEMOSTASIS ABNORMALITIES AND MASSIVE OBSTETRIC BLEEDING

Abstract

In spite of existing standards of hemorrhages prophylaxis maternal death from massive obstetric bleeding remains the main cause of maternal mortality in developing countries and even occurs in developed countries. The main risk factors of obstetrical bleedings are well known: placental abruption, placenta previa, uterus hypotonia, uterine rupture, amniotic fluid embolism, preeclampsia. However, these are only the tip of the iceberg. What is really assumed as a basis of majority of massive obstetric hemorrhages? From our view genetic thrombophilia, APS and hyperhomocysteinemia may be the etiopathogenetic risk factors of placental abruption, preeclampsia and respectively can be the cause of not only thromboembolic but hemorrhagic complications as well.

Keywords

• massive obstetric bleeding
• thrombophilia
• systemic inflammatory response syndrome
• dic-syndrome