Nature Communications (Nov 2020)

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

  • Ann Liza Piberger,
  • Akhil Bowry,
  • Richard D. W. Kelly,
  • Alexandra K. Walker,
  • Daniel González-Acosta,
  • Laura J. Bailey,
  • Aidan J. Doherty,
  • Juan Méndez,
  • Joanna R. Morris,
  • Helen E. Bryant,
  • Eva Petermann

DOI
https://doi.org/10.1038/s41467-020-19570-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.