Nature Communications (Aug 2017)

Exit from quiescence displays a memory of cell growth and division

  • Xia Wang,
  • Kotaro Fujimaki,
  • Geoffrey C. Mitchell,
  • Jungeun Sarah Kwon,
  • Kimiko Della Croce,
  • Chris Langsdorf,
  • Hao Helen Zhang,
  • Guang Yao

DOI
https://doi.org/10.1038/s41467-017-00367-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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The quiescence-exit process is noisy even in genetically identical cells under the same environmental conditions. Here the authors show that the heterogeneity of quiescence exit reflects a memory of preceding cell growth at quiescence induction and immediate division history prior to quiescence entry.