Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration

Hongping Yu; Yanyi Wang; Junjie Gao; Youshui Gao; Chao Zhong; Yixuan Chen

doi:10.1038/s42003-023-04567-x

Communications Biology (Feb 2023)

Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration

Hongping Yu,
Yanyi Wang,
Junjie Gao,
Youshui Gao,
Chao Zhong,
Yixuan Chen

Affiliations

Hongping Yu: Department of Orthopedic Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University
Yanyi Wang: Center for Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Junjie Gao: Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Youshui Gao: Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Chao Zhong: Center for Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Yixuan Chen: Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s42003-023-04567-x
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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The neuropeptide NPVF stimulates bone formation via the Wnt signaling pathway and hydroxyapatite scaffolds coated with NPVF stimulates angiogenesis and osteogenesis in a rat calvaria defect model.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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