Hardware and program system for determination of authenticity of medicines by nuclear quadrupole resonance method

Abstract

THE PURPOSE. Study the possibility of using a laboratory nuclear magnetic resonance console as a device for detecting counterfeit medicines. The problem of detecting counterfeit and counterfeit medicines is now very acute. Consider the potential of applying the nuclear quadrupole resonance radiospectroscopy method to determine the authenticity and quality of medicines by non-destructive means.ACTUALITY. The nuclear magnetic resonance method is included in the list of physico-chemical methods used in pharmacopia. The spectroscopy of nuclear quadrupole resonance, being similar in physical principles, has its advantages and advantages, which in general will strengthen the control of the authenticity and quality of medicines.METHODS. The theory of nuclear quadrupole resonance and features that allow to investigate medicinal preparations is resulted. The structural design of this hardware and software complex based on the Apollo Redstone nuclear quadrupole resonance spectrometer is described, its nodes are described, characteristics and parameters are given, a special attention is paid to the development of the sensor for the hardwarethe software complex and its coordination system with the spectrometer. Detailed description of its radio technical characteristics.RESULTS. The article shows the results of using the hardware software complex - measurements of spectra of nuclear quadrupole resonance for the drug paracetamol developed by various manufacturers, both Russia and foreign pharmaceutical companies. The possibility of measuring spectral characteristics directly in the package is shown. The necessary multi-pulse series of pulses, used in the measurement of spectral characteristics, are given. The possibility of receiving signals of spin echo with a good signal/noise ratio is shown, as well as the possibility of distinguishing different manufacturers' spectra of paracetamol according to the form of the release.CONCLUSION. The article shows a principal possibility of creation on the basis of this method of compact and portable devices for non-destructive identification of medicinal preparations.

Keywords

• nuclear quadrupole resonance
• the quality of medicines
• non-destructive testing
• increased sensitivity
• dual-frequency nqr