Медицинская иммунология (Jul 2014)

REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS

  • R. R. Khasanova,
  • O. V. Voronkova,
  • O. I. Urazova,
  • V. V. Novitsky,
  • A. K. Strelis,
  • Yu. V. Stambula,
  • A. E. Kolosova,
  • V. A. Serebryakova,
  • I. O. Naslednikova,
  • O. V. Kolokolova,
  • T. E. Budkina,
  • N. P. Pirogova

DOI
https://doi.org/10.15789/1563-0625-2009-1-35-40
Journal volume & issue
Vol. 11, no. 1
pp. 35 – 40

Abstract

Read online

Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant.

Keywords