Nature Communications (Oct 2018)
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
- Maolei Zhang,
- Kun Zhao,
- Xiaoping Xu,
- Yibing Yang,
- Sheng Yan,
- Ping Wei,
- Hui Liu,
- Jianbo Xu,
- Feizhe Xiao,
- Huangkai Zhou,
- Xuesong Yang,
- Nunu Huang,
- Jinglei Liu,
- Kejun He,
- Keping Xie,
- Gong Zhang,
- Suyun Huang,
- Nu Zhang
Affiliations
- Maolei Zhang
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Kun Zhao
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Xiaoping Xu
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Yibing Yang
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Sheng Yan
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Ping Wei
- Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University
- Hui Liu
- Department of Spine Surgery, First Affiliated Hospital of Sun Yat-sen University
- Jianbo Xu
- Department of Gastroenterology Surgery, First Affiliated Hospital of Sun Yat-sen University
- Feizhe Xiao
- Department of Scientific Research Section, First Affiliated Hospital of Sun Yat-sen University
- Huangkai Zhou
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Xuesong Yang
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Nunu Huang
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Jinglei Liu
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Kejun He
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- Keping Xie
- Department of Gastroenterology, University of Texas MD Anderson Cancer Center
- Gong Zhang
- Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University
- Suyun Huang
- Department of Neurosurgery, University of Texas MD Anderson Cancer Center
- Nu Zhang
- Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-018-06862-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.
