The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Ayşegül Erdem; Silvia Marin; Diego A. Pereira-Martins; Roldán Cortés; Alan Cunningham; Maurien G. Pruis; Bauke de Boer; Fiona A. J. van den Heuvel; Marjan Geugien; Albertus T. J. Wierenga; Annet Z. Brouwers-Vos; Eduardo M. Rego; Gerwin Huls; Marta Cascante; Jan Jacob Schuringa

doi:10.1038/s41467-022-28737-3

Nature Communications (Mar 2022)

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Ayşegül Erdem,
Silvia Marin,
Diego A. Pereira-Martins,
Roldán Cortés,
Alan Cunningham,
Maurien G. Pruis,
Bauke de Boer,
Fiona A. J. van den Heuvel,
Marjan Geugien,
Albertus T. J. Wierenga,
Annet Z. Brouwers-Vos,
Eduardo M. Rego,
Gerwin Huls,
Marta Cascante,
Jan Jacob Schuringa

Affiliations

Ayşegül Erdem: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Silvia Marin: Department of Biochemistry and Molecular Biology, Faculty of Biology
Diego A. Pereira-Martins: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Roldán Cortés: Department of Biochemistry and Molecular Biology, Faculty of Biology
Alan Cunningham: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Maurien G. Pruis: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Bauke de Boer: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Fiona A. J. van den Heuvel: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Marjan Geugien: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Albertus T. J. Wierenga: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Annet Z. Brouwers-Vos: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Eduardo M. Rego: Hematology Division, LIM31, Faculdade de Medicina, University of São Paulo
Gerwin Huls: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen
Marta Cascante: Department of Biochemistry and Molecular Biology, Faculty of Biology
Jan Jacob Schuringa: Department of Experimental Hematology, University Medical Center Groningen, University of Groningen

DOI: https://doi.org/10.1038/s41467-022-28737-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Acute myeloid leukemia (AML) is genetically a very heterogeneous disease. Here, Erdem et al. uncover heterogeneity in the metabolic landscape of AML and identify Pyruvate dehydrogenase kinase 1 (PDK1) as a targetable determinant of different metabolic states in distinct subtypes of AML.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal