An overview of cutaneous T cell lymphomas [version 1; referees: 2 approved]

Abstract

Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-Hodgkin’s lymphomas that are characterized by a cutaneous infiltration of malignant monoclonal T lymphocytes. They typically afflict adults with a median age of 55 to 60 years, and the annual incidence is about 0.5 per 100,000. Mycosis fungoides, Sézary syndrome, and primary cutaneous peripheral T cell lymphomas not otherwise specified are the most important subtypes of CTCL. CTCL is a complicated concept in terms of etiopathogenesis, diagnosis, therapy, and prognosis. Herein, we summarize advances which have been achieved in these fields.

Keywords

• Cell Growth & Division
• Cell Signaling
• Cellular Death & Stress Responses
• Control of Gene Expression
• Cutaneous Signs of Systemic Disease
• Developmental Molecular Mechanisms
• Genetics of the Immune System
• Immunopharmacology & Hematologic Pharmacology
• Leukocyte Signaling & Gene Expression
• Lymphomas & Myelomas
• Medical Genetics
• Photodermatology & Skin Aging
• Stem Cells & Regeneration