Photocatalytic defluoroalkylation and hydrodefluorination of trifluoromethyls using o-phosphinophenolate

Abstract

Photoredox catalysis can strongly reduce and cleave unactivated chemical bonds via photoinduced electron transfer. Here the authors use o-phosphinophenolate for photocatalytic C–F activation of a wide range of trifluoromethyl groups in trifluoroacetamides, trifluoroacetates, and trifluoromethyl(hetero)arenes to deliver corresponding difluoromethyl radicals.