Nature Communications (Mar 2016)
A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features
- Kaustubh Adhikari,
- Tania Fontanil,
- Santiago Cal,
- Javier Mendoza-Revilla,
- Macarena Fuentes-Guajardo,
- Juan-Camilo Chacón-Duque,
- Farah Al-Saadi,
- Jeanette A. Johansson,
- Mirsha Quinto-Sanchez,
- Victor Acuña-Alonzo,
- Claudia Jaramillo,
- William Arias,
- Rodrigo Barquera Lozano,
- Gastón Macín Pérez,
- Jorge Gómez-Valdés,
- Hugo Villamil-Ramírez,
- Tábita Hunemeier,
- Virginia Ramallo,
- Caio C. Silva de Cerqueira,
- Malena Hurtado,
- Valeria Villegas,
- Vanessa Granja,
- Carla Gallo,
- Giovanni Poletti,
- Lavinia Schuler-Faccini,
- Francisco M. Salzano,
- Maria-Cátira Bortolini,
- Samuel Canizales-Quinteros,
- Francisco Rothhammer,
- Gabriel Bedoya,
- Rolando Gonzalez-José,
- Denis Headon,
- Carlos López-Otín,
- Desmond J. Tobin,
- David Balding,
- Andrés Ruiz-Linares
Affiliations
- Kaustubh Adhikari
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Tania Fontanil
- Departamento de Bioquímica y Biología Molecular, IUOPA, Universidad de Oviedo
- Santiago Cal
- Departamento de Bioquímica y Biología Molecular, IUOPA, Universidad de Oviedo
- Javier Mendoza-Revilla
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Macarena Fuentes-Guajardo
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Juan-Camilo Chacón-Duque
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Farah Al-Saadi
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Jeanette A. Johansson
- Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
- Mirsha Quinto-Sanchez
- Centro Nacional Patagónico, CONICET
- Victor Acuña-Alonzo
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Claudia Jaramillo
- GENMOL (Genética Molecular), Universidad de Antioquia, Medellín 5001000, Colombia
- William Arias
- GENMOL (Genética Molecular), Universidad de Antioquia, Medellín 5001000, Colombia
- Rodrigo Barquera Lozano
- National Institute of Anthropology and History
- Gastón Macín Pérez
- National Institute of Anthropology and History
- Jorge Gómez-Valdés
- Facultad de Medicina, UNAM
- Hugo Villamil-Ramírez
- Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica
- Tábita Hunemeier
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Virginia Ramallo
- Centro Nacional Patagónico, CONICET
- Caio C. Silva de Cerqueira
- Centro Nacional Patagónico, CONICET
- Malena Hurtado
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú
- Valeria Villegas
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú
- Vanessa Granja
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú
- Carla Gallo
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú
- Giovanni Poletti
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú
- Lavinia Schuler-Faccini
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Francisco M. Salzano
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Maria-Cátira Bortolini
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Samuel Canizales-Quinteros
- Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica
- Francisco Rothhammer
- Instituto de Alta Investigación, Universidad de Tarapacá
- Gabriel Bedoya
- GENMOL (Genética Molecular), Universidad de Antioquia, Medellín 5001000, Colombia
- Rolando Gonzalez-José
- Centro Nacional Patagónico, CONICET
- Denis Headon
- Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
- Carlos López-Otín
- Departamento de Bioquímica y Biología Molecular, IUOPA, Universidad de Oviedo
- Desmond J. Tobin
- Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford
- David Balding
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Andrés Ruiz-Linares
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- DOI
- https://doi.org/10.1038/ncomms10815
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
By examining Latin American individuals of mixed European, Native American and African ancestry, Adhikari et al. identify novel loci influencing various features of facial and scalp hair. The study also provides experimental evidence that one of the implicated genes (PRSS53) is expressed in the hair follicle and that the top associated variant alters processing of this enzyme.
