Journal of Clinical & Translational Endocrinology (Dec 2017)
The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study
- Claire K. Inman,
- Abdullah Aljunaibi,
- Hyunwook Koh,
- Abdishakur Abdulle,
- Raghib Ali,
- Abdullah Alnaeemi,
- Eiman Al Zaabi,
- Naima Oumeziane,
- Marina Al Bastaki,
- Mohammed Al-Houqani,
- Fatma Al-Maskari,
- Ayesha Al Dhaheri,
- Syed M. Shah,
- Laila Abdel Wareth,
- Wael Al Mahmeed,
- Habiba Alsafar,
- Fatme Al Anouti,
- Ayesha Al Hosani,
- Muna Haji,
- Divya Galani,
- Matthew J. O'Connor,
- Jiyoung Ahn,
- Tomas Kirchhoff,
- Scott Sherman,
- Richard B. Hayes,
- Huilin Li,
- Ravichandran Ramasamy,
- Ann Marie Schmidt
Affiliations
- Claire K. Inman
- Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Abdullah Aljunaibi
- Department of Pediatrics, Zayed Military Hospital, Abu Dhabi, United Arab Emirates
- Hyunwook Koh
- Department of Population Health, New York University School of Medicine, New York, NY, USA
- Abdishakur Abdulle
- Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Raghib Ali
- Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Abdullah Alnaeemi
- Department of Cardiology, Zayed Military Hospital, Abu Dhabi, United Arab Emirates
- Eiman Al Zaabi
- Department of Pathology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
- Naima Oumeziane
- Abu Dhabi Blood Bank, SEHA, Abu Dhabi, United Arab Emirates
- Marina Al Bastaki
- Abu Dhabi Blood Bank, SEHA, Abu Dhabi, United Arab Emirates
- Mohammed Al-Houqani
- Department of Medicine, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates
- Fatma Al-Maskari
- Institute of Public Health, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates
- Ayesha Al Dhaheri
- Department of Nutrition, College of Architecture, UAE University, Al-Ain, United Arab Emirates
- Syed M. Shah
- Institute of Public Health, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates
- Laila Abdel Wareth
- Pathology and Laboratory Medicine Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates
- Wael Al Mahmeed
- Department of Cardiovascular Medicine, Cleveland Clinic, Abu Dhabi, United Arab Emirates
- Habiba Alsafar
- Center for Biotechnology, Khalifa University of Science, Technology & Research, Abu Dhabi, United Arab Emirates; Biomedical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
- Fatme Al Anouti
- College of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates
- Ayesha Al Hosani
- Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Muna Haji
- Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Divya Galani
- Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Matthew J. O'Connor
- New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
- Jiyoung Ahn
- Department of Population Health, New York University School of Medicine, New York, NY, USA
- Tomas Kirchhoff
- Department of Population Health, New York University School of Medicine, New York, NY, USA
- Scott Sherman
- Department of Population Health, New York University School of Medicine, New York, NY, USA
- Richard B. Hayes
- Department of Population Health, New York University School of Medicine, New York, NY, USA
- Huilin Li
- Department of Population Health, New York University School of Medicine, New York, NY, USA
- Ravichandran Ramasamy
- Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine New York University School of Medicine, New York, NY, USA; Corresponding authors at: Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, 550 First Avenue, Smilow 904, NY, NY 10016, USA (R. Ramasamy). Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, 550 First Avenue, Smilow 901C, NY, NY 10016, USA (A.M. Schmidt).
- Ann Marie Schmidt
- Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine New York University School of Medicine, New York, NY, USA; Corresponding authors at: Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, 550 First Avenue, Smilow 904, NY, NY 10016, USA (R. Ramasamy). Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, New York University School of Medicine, 550 First Avenue, Smilow 901C, NY, NY 10016, USA (A.M. Schmidt).
- Journal volume & issue
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Vol. 10
pp. 1 – 8
Abstract
Aims: The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods: 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results: After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions: The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS. Keywords: Advanced glycation endproducts (AGEs), Receptor for AGE (RAGE), Cohort study, Diabetes mellitus, Obesity
