Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation

Abstract

Highlights In a focal rat DTH-EAE model of neuroinflammation, dimethyl fumarate decreases the uptake of TSPO PET tracer [18F]GE-180 in the short term. Long-term [18F]GE-180 follow-up did not indicate a treatment effect. Decreased neuroinflammation, CD4+ T cell infiltration, and CD8+ T cell infiltration were detected using immunohistochemistry.

Keywords

• Multiple sclerosis
• fDTH-EAE
• Dimethyl fumarate
• BG-12
• [18F]GE-180