Journal Title: Frontiers in Neural Circuits
ISSN: 1662-5110 (Online)
Publisher: Frontiers Media S.A.
LCC Subject Category: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Country of publisher: Switzerland
Language of fulltext: English
Full-text formats available: PDF, HTML, ePUB, XML
William Martin Connelly (Australian National University)
William Martin Connelly (Cardiff University)
Michael eLaing (Cardiff University)
Adam Clarke Errington (Cardiff University)
Vincenzo eCrunelli (Cardiff University)
Vincenzo eCrunelli (University of Malta)
Abstract | Full Text
In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiological parameters, we show that the thalamus behaves akin to a low pass filter. Specifically, as individual cells in the thalamus rely on consistent drive to spike, stimuli that is rapidly and continuously changing over time such that it activates sensory cells with different receptive fields are unable to drive thalamic spiking. This means that thalamic encoding is robust to sensory noise, however it induces a lag in sensory representation. Thus the thalamus stabilises encoding of sensory information, at the cost of response rate.