Distribution of Serotypes and Genotypes of Rotavirus Strains in Nigerian Children

Abstract

Summary: Polymerase chain reaction and radioactive dotblot hybridisation techniques were used to analyse 45 rotavirus-positive stool samples for G (serotype) and P(genotype) distribution among Nigerian children. While samples bearing G1 specificities predominated among the females, those bearing serotype G3 were more prevalent among the males (P<0.05). VP4 genotypes were evenly distributed among both sexes. Strain type GIP8 was more prevalent among the females than the males (P<0.05). The results demonstrate that differences in serotype, genotype and strain distribution among male and fe male children exist and these differences may be of relevance in formulating the type of vaccine suitable for each gender population.