An explainable model of host genetic interactions linked to COVID-19 severity

Anthony Onoja; Nicola Picchiotti; Chiara Fallerini; Margherita Baldassarri; Francesca Fava; GEN-COVID Multicenter Study; Francesca Colombo; Francesca Chiaromonte; Alessandra Renieri; Simone Furini; Francesco Raimondi

doi:10.1038/s42003-022-04073-6

Communications Biology (Oct 2022)

An explainable model of host genetic interactions linked to COVID-19 severity

Anthony Onoja,
Nicola Picchiotti,
Chiara Fallerini,
Margherita Baldassarri,
Francesca Fava,
GEN-COVID Multicenter Study,
Francesca Colombo,
Francesca Chiaromonte,
Alessandra Renieri,
Simone Furini,
Francesco Raimondi

Affiliations

Anthony Onoja: Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore
Nicola Picchiotti: University of Siena, DIISM-SAILAB
Chiara Fallerini: Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena
Margherita Baldassarri: Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena
Francesca Fava: Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena
GEN-COVID Multicenter Study
Francesca Colombo: Istituto di Tecnologie Biomediche—Consiglio Nazionale delle Ricerche
Francesca Chiaromonte: Dept. of Statistics and Huck Institutes of the Life Sciences, Penn State University
Alessandra Renieri: Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena
Simone Furini: Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena
Francesco Raimondi: Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore

DOI: https://doi.org/10.1038/s42003-022-04073-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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A multifaceted computational strategy identifies 16 genetic variants contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing dataset of a cohort of Italian patients.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal