The study of antiexudative action of S-alkylated 1,3,4-oxadiazole-3-thionе derivatives

Abstract

Despite the popularity and efficiency of non-steroidal anti-inflammatory drugs and their widespread usage in clinical practice, this group of drugs is also characterized by numerous side effects, so obtaining of new safe NSAIDs is one of the priority tasks for modern pharmaceutical and medical chemistry. Aim. Studying of the anti-inflammatory activity of S-alkylated 1,3,4-oxadiazole-2-thiol derivatives with diclofenac fragment in the molecules. Materials and methods. The study of antiexudative activity of the compounds was carried out on the model of carrageenan-induced rat paw inflammation, quantitatively the effect was estimated by the index of inhibition of the inflammatory reaction. Results. During the research, highly active S-alkylated derivatives of 1,3,4-oxadiazole-2-thiol with antiexudative activity in the range of 42.4–44.6 % were identified, which is commensurate with the effects of the reference drugs diclofenac sodium and ketorolac. Conclusions. The obtained results indicate the presence of high antiexudative activity in a group of S-alkylated 1,3,4-oxadiazole-2-thiol derivatives, which actualizes the in-depth study of this class of heterocyclic compounds.

Keywords

• anti-inflammatory activity
• carrageenan-induced rat paw inflammation
• diclofenac
• s-alkylated 1 3 4-oxadiazole-2-thiols