Disorders of the aggregation function of platelets against the background of a deficiency of certain vitamins and microelements in children

Abstract

The purpose of the work is the relevance of multilevel influence of deficiency of some nutrients on children's health. Nowadays, "unexplained" hemorrhagic syndrome is quite common in children. At the same time, standard methods of examination of patients do not allow to establish the cause of such pathology. Only a targeted study of the primary hemostasis will reveal dysaggregative thrombocytopathy. Often thrombocytopathies in children have an erased clinical picture and are not diagnosed in time. It is now known that increased platelet aggregation can be regarded as a predictor of the development of pathological disorders in the cardiovascular and other systems. Also increased platelet aggregation can lead to small vessel wall remodeling. The mechanisms of platelet activation are different. They depend on blood plasma composition, functional state and structure of both platelet membranes and functional state of endothelium. The clinical picture of platelet disorders of the hemostasis system is heterogeneous and includes hemorrhagic, ischemic and thrombotic manifestations. Diseases characterized by platelet disorders are not limited to congenital conditions. Often, against the background of any disease develops thrombocytopathies of an acquired nature. Abnormalities of platelet hemostasis are observed in patients of different profiles. The results of research of blood test results, level of serum iron, ferritin, vitamin B12, vitamin D demonstrated the presence of deficiency and insufficiency of microelements in children. The article presents data from laboratory studies reflecting abnormalities in platelet function on the background of vitamin B9, B12, D deficiency and decreased iron reserves. The results indicate the relevance of timely versatile examination of the pediatric population for the diagnosis of deficiencies of the main micronutrients and platelet diseases acquired on this background.

Keywords

• platelets
• aggregation
• hemostasis
• deficiency
• vitamins