ST2 myocardial stress marker research in patients with obstructive sleep apnea and gastroesophageal reflux disease

Abstract

Objective – To investigate the ST2 marker dynamics in the serum in patients with combined obstructive sleep apnea (OSA) and gastroesophageal reflux disease (GERD) and analyze its relationship with myocardial dysfunction. Materials and methods. 135 patients were examined at the Educational and Scientific Medical Center of ZSMU “University Clinic”: group I – 31 patients with GERD, group II – 32 patients with OSA, group III – 72 patients with OSA and GERD. The control group consisted of 30 healthy individuals. The patients’ average age was 48 (36; 58) years. The groups were comparable by age, gender composition. The myocardial stress marker ST2 serum level was examined in all patients. The results of dispersive ECG mapping, daily monitoring of ECG and blood pressure, and echocardioscopy were evaluated. Results. In patients with OSA and GERD combined course, 2-fold increase in the ST2 marker was detected compared with patients in the control group, with patients in group I – by 1.66 times, with patients in group II – by 1.36 times (P < 0.05). Significant correlation between ST2 level and the apnea-hypopnea index (ANI), heart rate variability parameters, the “Myocardium” index according to the dispersive ECG mapping and the left ventricular diastolic function parameters according to echocardioscopy was revealed. Conclusions. Patients with a comorbid course of obstructive sleep apnea and gastroesophageal reflux disease have higher level of the ST2 marker. Serum ST2 concentration correlates with cardiovascular disorders in patients with combined OAS and GERD.

Keywords

• obstructive sleep apnea
• gastroesophageal reflux disease
• st2 marker of myocardial stress
• myocardial disfunction