Pathogens (Jul 2023)

G6P[8] Rotavirus a Possessing a Wa-like VP3 Gene from a Child with Acute Gastroenteritis Living in the Northwest Amazon Region

  • Marcia Terezinha Baroni de Moraes,
  • Mauro França da Silva,
  • Yan Cardoso Pimenta,
  • Carina Pacheco Cantelli,
  • Rosane Maria Santos de Assis,
  • Alexandre Madi Fialho,
  • Marina Galvão Bueno,
  • Alberto Ignácio Olivares Olivares,
  • Lennart Svensson,
  • José Paulo Gagliardi Leite,
  • Johan Nordgren

DOI
https://doi.org/10.3390/pathogens12070956
Journal volume & issue
Vol. 12, no. 7
p. 956

Abstract

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The introduction of rotavirus A (RVA) vaccines has considerably reduced the RVA-associated mortality among children under 5 years of age worldwide. The ability of RVA to reassort gives rise to different combinations of surface proteins G (glycoprotein, VP7) and P (protease sensitive, VP4) RVA types infecting children. During the epidemiological surveillance of RVA in the Northwest Amazon region, an unusual rotavirus genotype G6P[8] was detected in feces of a 2-year-old child with acute gastroenteritis (AGE) that had been vaccinated with one dose of Rotarix® (RV1). The G6P[8] sample had a DS-1-like constellation with a Wa-like VP3 gene mono-reassortment similar to equine-like G3P[8] that has been frequently detected in Brazil previously. The results presented here reinforce the evolutionary dynamics of RVA and the importance of constant molecular surveillance.

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