Hepatic Medicine: Evidence and Research (Jul 2022)
Clinical, Laboratory and Bacterial Profile of Spontaneous Bacterial Peritonitis in Vietnamese Patients with Liver Cirrhosis
Abstract
Long Cong Nguyen,1,2 Thuy Thi-Bich Lo,3 Huong Dieu La,1 Ha Thi-Ngoc Doan,1 Ngoan Tran Le4,5 1Gastroenterology and Hepatology Center, Bach Mai Hospital, Hanoi, Vietnam; 2University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam; 3Hung Vuong hospital, Ho Chi Minh City, Phu Tho, Vietnam; 4Institute of Research and Development, Duy Tan University, Da Nang, Vietnam; 5Department of Public Health, School of Medicine, International University of Health and Welfare, Tochigi, JapanCorrespondence: Long Cong Nguyen, Institution: Gastroenterology and Hepatology Center, Bach Mai hospital, Hanoi, Vietnam, Email [email protected]: To determine several clinical and laboratory features as well as the bacterial profile of spontaneous bacterial peritonitis (SBP) in 58 Vietnamese patients admitted to a single center due to liver cirrhosis.Methods: We retrospectively analyzed bacteriological, clinical and laboratory characteristics of patients with SBP admitted to the Gastroenterology and Hepatology Center from July 2019 to July 2020.Results: Out of a total 58 SBP patients, 41 (70.9%) had culture-negative neutrocytic ascites. The majority of patients experienced abdominal pain (93,1%) and large ascites (65,5%). Gram-negative bacteria formed the main pathogens (14/17). Escherichia coli (9/17) was the predominant cause followed by Burkholderia cepacia (2/17). Antibiotic sensitivity rate of E. coli for third generation cephalosporin was low but high for aminoglycoside and carbapenem antibiotics. The resistance of E. coli was significant against fluoroquinolones (100%). All 3 cases of gram-positive bacteria were sensitive to vancomycin.Conclusion: Our study reported the bacteriological and clinical characteristics of patients with SBP and compared these findings between two groups: positive ascitic fluid culture and negative fluid culture. Ascitic fluid culture can guide for the right antibiotic choice since resistance to commonly prescribed antibiotics is common in SBP patients.Keywords: liver cirrhosis, peritonitis, ascitic fluid, antibiotic sensitivity
