Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
Julia Nowowiejska,
Anna Baran,
Justyna Magdalena Hermanowicz,
Joanna Mikłosz,
Karol Adam Kamiński,
Marcin Kondraciuk,
Marlena Dubatówka,
Dariusz Pawlak,
Iwona Flisiak
Affiliations
Julia Nowowiejska
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland
Anna Baran
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland
Justyna Magdalena Hermanowicz
Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C St, 15-540 Bialystok, Poland
Joanna Mikłosz
Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C St, 15-540 Bialystok, Poland
Karol Adam Kamiński
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Waszyngtona 13 St, 15-269 Bialystok, Poland
Marcin Kondraciuk
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Waszyngtona 13 St, 15-269 Bialystok, Poland
Marlena Dubatówka
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Waszyngtona 13 St, 15-269 Bialystok, Poland
Dariusz Pawlak
Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C St, 15-540 Bialystok, Poland
Iwona Flisiak
Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St, 15-540 Bialystok, Poland
Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum concentration has been proposed as a biomarker of cardiometabolic complications, especially coronary artery disease (CAD). The study involved 56 patients with abovementioned dermatoses and 29 sex- and age-matched volunteers without dermatoses. ANGPTL4 serum concentration was measured by ELISA. ANGPTL4 concentration was statistically significantly higher in patients with LP compared to the control group (p p p < 0.01, respectively). There was no statistically significant difference in ANGPTL4 concentration between patients with psoriasis or vitiligo and controls. There was no correlation between ANGPTL4 concentration and age or BMI in all study groups. There was a positive correlation between ANGPTL4 concentration and fasting glucose (R = 0.43) and AST activity (R = 0.39) in psoriatic patients and ALT activity in patients with vitiligo (R = 0.44). ANGPTL4 could be a potential marker of metabolic complications in patients with LP, especially CAD. Perhaps patients with LP are more prone to CAD compared to the other two dermatoses, which requires further research.
